Potential interaction likely to be of weak intensity. Potential clinically significant interaction that is likely to require additional monitoring, alteration of drug dosage or timing of administration. Paxlovid Advice for administering COVID-19 therapies (licensed or under clinical investigation) to patients who cannot swallow is given in this PDF. From 1 November 2022, medical practitioners and nurse practitioners can add Paxlovid to Prescribers Bag supplies. Paxlovid side effects. Interactions WebThis document does not contain all possible drug interactions. [25], As of May2022[update], the effectiveness of nirmatrelvir/ritonavir among vaccinated people was unknown. PAXLOVID [20] The drug does not prevent infection in people who live with an infected person. On day 3 of treatment, the patient presented with signs and symptoms of fatigue and bradycardia, with a heart rate below 40 beats per minute. Box 1 lists select outpatient medications that are not expected to have clinically relevant interactions with ritonavir-boosted nirmatrelvir. In summary, despite theoretical concerns of DDI with paxlovid, the clinical reality for the brief course of treatment is reassuring. Other resources regarding management of drugs with potentially significant drug interactions with Paxlovid include: NIH COVID-19 Treatment Guidelines University of Liverpool COVID-19 Drug Interactions The patient has disability with multiple comorbidities and/or frailty. Paxlovid is an oral antiviral medicine which can be used by patients with mild to moderate COVID-19 who have a high risk for developing severe disease, reducing the need for admission to hospital. Confirmation of a positive home rapid antigen diagnostic test with additional direct SARS-CoV-2 viral testing, such as a PCR, is not required. Incidentally, the practitioner who reported this event to ISMP mentioned that the prescriber was not familiar with the patients medical history.
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