Some people may use goldenseal for canker sores (ulcers in the mouth). Cancer Lett 1-1-2000;148(1):19-25. Am J Chin Med 2012;40(5):887-904. View abstract. Arzneimittelforschung. Therefore, these herbs may have different side effects and drug interactions than those associated with goldenseal (42). Drug Metab Dispos 2007;35:240-5. Lin, J. G., Chung, J. G., Wu, L. T., Chen, G. W., Chang, H. L., and Wang, T. F. Effects of berberine on arylamine N-acetyltransferase activity in human colon tumor cells. It is available in: Follow the dosing guidelines on the packaging of the goldenseal product you are using. Traditional Japanese herbal (kampo) medicines and treatment of ocular diseases: a review. Infantsparticularly newbornsmight get kernicterus from goldenseal. Chin J Integr Med 2005;11:217-21. Berberine in the treatment of diarrhoea of infancy and childhood. Cancer Lett. Diabetes Care 2011;34 Suppl 2:S279-84. GOLDENSEAL Reviews and User Ratings: Effectiveness, Ease of Use, and Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Am J Vet Res 1982;43(9):1594-1598. 2012;79(9). Indian J Med Res 1976;64(8):1160-1167. Berberine-containing plants like goldenseal may benefit your skin. Liu CX, Xiao PG, and Liu GS. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Fukuda, K., Hibiya, Y., Mutoh, M., Koshiji, M., Akao, S., and Fujiwara, H. Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. View abstract. Please review this supplement label with your healthcare provider to discuss potential interactions with foods, other supplements, and medications. Scientific research suggests that medicinal plants like goldenseal and, research at the University of Texas-Houston Medical School, There havent been any clinical (human) studies to date, but goldenseal is also sometimes recommended to treat, For example, one in vitro study published in the journal, berberine inhibited the growth of breast cancer cells to a greater extent than doxorubicin, Berberine alkaloids have also been shown during in vivo studies to have potent cancer cell killing activity against tumor cells. Goldenseal gets its name from its yellow and brown roots. Rehman J, Dillow JM, Carter SM, and et al. View abstract. Clin Pharmacol Ther 2005;77:415-26. J Diarrhoeal Dis Res 1992;10(4):201-204. Inhibition of the bacterial surface protein anchoring transpeptidase sortase by isoquinoline alkaloids. Biol Pharm Bull 1999;22(4):391-396. For example, you may experience the following: If you're having a severe allergic reaction or if any of your symptoms feel life-threatening, call 911 and get medical help right away. Journal of the Indian Medical Association 1967;48(1):1-11. Horn JR, Hansten PD. So, taking it with blood sugar medicationslike insulinmay further lower your blood sugar. Berberine has been extensively researched and has been . J Clin Endocrinol Metab 2008;93:2559-65. There are several different sources of goldenseal. Mol Nutr Food Res 2008;52:755-63. View abstract. Sharma R, Joshi CK, and Goyal RK. J Clin Endocrinol.Metab 2008;93(7):2559-2565. In Vivo 2005;19(1):247-252. Studies suggest that berberine, one of the main compounds in goldenseal, may reduce sugar absorption from the gut, lower insulin resistance, and promote insulin secretion all of which are factors that may help lower blood sugar levels (46). Potentially similar supplements may include the following: Don't combine multiple natural products until you first talk with your healthcare provider or pharmacist.