"Nevertheless, even if the active pharmaceutical ingredient (API) itself is not patentable as a chemical entity, it may be possible to obtain patent protection for a drug candidate that combines the API with an effective, patentable drug delivery technology.. What they do realize is that the cannabinoid isolated from this liverwort, and THC found in Cannabis are chemically similar , but also produce quite similar effects in the brains of mammals. Gaoni Y., Mechoulam R., Isolation, structure, and partial synthesis of an active constituent of Hashish. Indacloud. Because the plants make so little of the substance, researchers have struggled to study its effects, until now. Invest in quality science journalism by donating today. Whether or not a sale of tangible personal property is properly The licensable privilege of wholesale selling. Discoveries come from the oddest places. Stereodivergent synthesis of S N Ar precursors. Can you tell how many chloroplasts are in it? The work of Jrg Gertsch and colleagues is a prominent advance in understanding the role of plants beyond cannabis on the endocannabinoid system, said Ethan Russo M.D., a neurologist, and Director of Research and Development for International Cannabis and Cannabinoids Institute (ICCI). Dies ist ein Beispiel-Widget, dass dir zeigt, wie die rechte Seitenleiste Standardmig aussieht. Russo added. Careers. Biodivers. 2. 15, 757764 (2014). Endocannabinoids are produced naturally in our bodies (e.g. Each archegonium produces a single haploid egg by mitosis. Moreover, the API could be the subject of a method of treatment patent if the API is discovered to be a novel treatment for a disease indication, added Wesner. Reagents and conditions: (f) 1.6 equiv, Fig. But PETs more potent anti-inflammatory effects, compared with THC, based on initial studies, certainly became a point of further interest. Our findings may have implications for bioprospecting and drug discovery and provide a molecular rationale for the reported effects upon consumption of certain Radula preparations as moderately active legal highs. Epub 2014 Apr 1. Theres plenty of chatter on internet drug forums about using Radula as a legal high, but theres not much scientific research on the plant, which is native to New The liverwort compound may also have fewer negative side effects such as memory loss and loss of coordination, he says. Obtain a prepared slide of an unfertilized Marchantia archegoniophore. 4, 16141648 (2007). keep on posting! Choosing a selection results in a full page refresh. To explore how cis-PET affects the brain, Gertsch and his colleagues injected it into the abdomens of mice and observed how it interacted with 44 different targets in the central nervous system. Chicca, M. A. Schafroth, I. Reynoso-Moreno, R. Erni, V. Petrucci, E. M. Carreira, J. Gertsch. 12 grams or less of hash or other forms of concentrate. Label the bolded features in the life cycle diagram. Liverwort produces a unique chemical that is eerily similar to THC, and as a result, it offers a wide range of comparable euphoric effects.