Fleisher In conclusion, patients who require repeated FNAs for indeterminate diagnoses will be resolved by repeat FNA in a percentage of 72%-80%. In this review we analyze all literature regarding Thyroid Cytopathology Reporting systems trying to identify the most suitable methodology to use in clinical practice for the preoperative diagnosis of thyroid nodules. Why do some investigations yield more, or less, information than others? A The National Cancer Institute Thyroid fine needle aspiration state of the science conference: a summation. %%EOF Use freshly squeaky-cleaned slides. Another pitfall encountered with cystic thyroid nodules are the atypical cyst-lining cells[24]. Carcinoma of the thyroid. The general category malignant is used whenever the cytomorphologic features are conclusive for malignancy. Figure 4. Several systems have been proposed for the cyropathologic diagnosis of the thyroid nodules. Descriptive comments that follow are used to subclassify the malignancy and summarize the results of special studies, if any. Baloch ZW, Cibas ES, Clark DP, Layfield LJ, Ljung BM, Pitman MB, Abati A. Rossi Several patterns of nuclear atypia may be also present without being quantitatively and/or qualitatively sufficient for the interpretation of suspicious for malignancy. Hay If the nodule is almost entirely cystic, with no worrisome sonographic features, an endocrinologist might proceed as if the CFO were a benign result. The presence of true psammoma bodies with concentric laminations is highly suggestive of PTC; however the presence of psammoma bodies in cystic thyroid lesions is not diagnostic. Baloch This category includes the diagnoses of nodular goiter, nodular goiter with hyperplastic nodules, colloid nodules, cyst contents with/without benign follicular cells, and lymphocytic thyroiditis; (3) DC III Atypia of Undetermined Significance or Follicular Lesion of Undetermined Significance (Figure (Figure2).2). Gross specimen was measuring about 2x2x1.5 cm in size, soft in consistency, brownish black in color and roughly oval in shape [Table/Fig-4]. VanderLaan PA, Marqusee E, Krane JF. These specimens demonstrate inadequate cellularity, poor fixation and preservation, obscuring blood or ultrasound gel, or a combination of the above factors. Melton The nuclear chromatin appears as salt and pepper type in a medullary carcinoma case ( 40 pap stain on ThinPrep slide) (diagnostic categories VI). This distinction cannot be made by FNA and is of no consequence to the patient. The main purpose of thyroid FNA is to identify patients with higher risk for malignancy, and to prevent unnecessary surgeries for benign conditions. Lymphoepithelial cyst.
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