D, I, Ortqvist Covid vaccine injury C, Oliva Second, potentially eligible records were further evaluated using the full texts. Diagnosis of anosmia and hyposmia: a systematic review. WebThe most frequent neurological side effects of SARS-CoV-2 vaccines are headache, Guillain-Barre syndrome (GBS), venous sinus thrombosis (VST), and transverse myelitis. Only a small number of studies (mostly case reports) reported data on the treatments and outcomes and mainly used steroids and antivirals as the treatment of choice (eTable 2 in Supplement 1). More discrete side effects connected to COVID-19 vaccines have been recognized, including a rare but severe clotting disorder that occurs after the AstraZeneca S, Kaur M, Zamani , Falsey 2022 Jul;92(1):157-158. doi: 10.1002/ana.26369. A, Cabrera One proposed mechanism is nerve compression within the temporal bone due to the perineural inflammation and subsequent edematous nerve bundles in response to viral infections,102 such as herpes zoster, varicella zoster,60 or Epstein-Barr viruses.103 These neurotropic viruses are also reportedly associated with neurologic complications, such as GBS, neuropathies, olfactory dysfunction, aseptic meningitis, and encephalitis.104-106 Similarly, vaccination has been a crucial means to reduce this overwhelming burden of viral infections for these viruses. Safety of quadrivalent meningococcal conjugate vaccine in 11- to 21-year-olds. . Four RCTs35-38,101 that reported BP as an adverse event were included in the first meta-analysis. Accessibility Statement, Our website uses cookies to enhance your experience. Non-Arteritic Ischemic Optic Neuropathy Following COVID-19 Vaccination in Korea: A Case Series. , Sekiguchi Notably, none of the studies had any data from children younger than 12 years, and this inclusion bias impedes the generalizability of the findings to this younger age range. Published Online: April 27, 2023. doi:10.1001/jamaoto.2023.0160. Three of the 5 RCTs had a low risk of bias,35-37 and 2 were unclear38,58 in the criterion D5: detection bias of the Cochrane assessment tool but were low risk in the rest of the criteria. This systematic review and meta-analysis of pooled randomized clinical trials found that the incidence of BP was significantly higher in vaccine vs placebo recipients. A, Floridi H, Kim Vaccines and Related Biological Products Advisory Committee meeting December 10, 2020. M, Ewers It can affect the PNS. et al. R. 2023 Apr 18:S1043-2760(23)00055-3. doi: 10.1016/j.tem.2023.03.002. This article is protected by copyright. , Wachira et al. , Assiri However, these tend to be rare. et al. Individuals over the age of 65 can receive a second updated COVID-19 vaccineeither Pfizer or Moderna at least four months after their last updated dose. The Cochrane Collaborations tool for assessing risk of bias in randomised trials. R, Gujrati After removing duplicate records, 2 independent researchers (Y.P. Vaccine Adverse Event Reporting System Could Miss or Misinterpret Neurological Side Effects of COVID-19 Vaccinations. , Davidov Accessed July 2, 2022. . et al. NA, Harakeh Rosenblum HG, Hadler SC, Moulia D, Shimabukuro TT, Su JR, Tepper NK, Ess KC, Woo EJ, Mba-Jonas A, Alimchandani M, Nair N, Klein NP, Hanson KE, Markowitz LE, Wharton M, McNally VV, Romero JR, Talbot HK, Lee GM, Daley MF, Mbaeyi SA, Oliver SE.
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