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We couldnt do what we do without our volunteers and donors. DermNet provides Google Translate, a free machine translation service. Treatment read more , which develop in the flat cells that form the outermost layer of skin, and 5% are melanomas Melanoma Melanoma is a skin cancer that begins in the pigment-producing cells of the skin (melanocytes). The cancer usually grows slowly over several years. Vulval lichen sclerosus. See Drugs Approved to Treat Vulvar Cancer for more information. Radiation therapy for vulvar cancer is usually administered by a machine that moves around your body and directs radiation to precise points on your skin (external beam radiation). In vulvar intraepithelial neoplasia (VIN), abnormal cells are found on the surface of the vulvar skin. Some women may experience additional symptoms such as: Other less common types of vulvar tumor include: The main cause of squamous cell cancer of the vulva is human papillomavirus (HPV) infection in at least half of the cases. As a rule, the lower the number, the less the cancer has spread. Dermoscopy of a vulval malignant melanoma The content of PDQ documents can be used freely as text. The risk of developing vulvar cancer is increased by the following: Human papillomavirus (HPV) infection Human Papillomavirus (HPV) Infection Human papillomavirus (HPV) can be sexually transmitted and causes changes in cells, which can lead to genital warts or to precancer or cancer of the cervix, vagina, vulva, anus, or throat. It usually appears on skin thats exposed to the sun, rarely on the vulva. Cancer.org is provided courtesy of the Leo and Gloria Rosen family. DNA tests from vulvar cancers in older women rarely show HPV infection, but often show mutations of the p53 tumor suppressor gene. Vulvar Cancer | OCRA Different types of treatments are available for patients with vulvar cancer. Vulval lichen sclerosus. As more women live longer, this cancer is likely to become more common. Recent evidence suggests that vulvar cancer is becoming more common among younger women. This starts in bone, muscle, or connective tissue cells. WebMD does not provide medical advice, diagnosis or treatment. It might be linked to the human papillomavirus (HPV), especially in younger women.